circRNA basic information
circBase ID: -
Name: hsa_circ_TLK1
Synonym: -
Host Gene: TLK1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

glioma tissues; adjacent normal tissues; cancerous tissue; normal adjacent tissues
Cell lines:

HEB; U251; A172; SF-539; Hs683; HTB-138
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: PANX1, MAPK/ERK, VEGFA, PDGF, MMP3, HIF-1alpha
Associated microRNA: miR-17-5p
Biological function: Circ-TLK1 promotes glioma growth, proliferation, migration, invasion and metastasis, inhibits apoptosis, and accelerates tumor growth in vivo.
Molecular mechanism: Circ-TLK1 acts as a competing endogenous RNA by sponging miR-17-5p, thereby up-regulating PANX1 and activating the MAPK/ERK pathway in glioma.
Biological pathway or process:

MAPK (promotes); ERK (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); angiogenesis (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot; IHC (Immunohistochemistry); TUNEL; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Up-regulated Circ-TLK1 was significantly correlated with larger tumor volume, higher WHO grades, and poorer survival rate in glioma patients.
Description:

Circ-TLK1 is up-regulated in glioma tissues and cell lines and high expression is associated with larger tumor volume, higher grade, and poorer survival. Functionally, Circ-TLK1 promotes glioma proliferation, migration, invasion, metastasis and in vivo tumor growth while inhibiting apoptosis. Mechanistically, it sponges miR-17-5p to up-regulate PANX1 and activate MAPK/ERK signaling.
Confidence score:

0.7412
Other information
Title:

Inhibiting of circ-TLK1 inhibits the progression of glioma through down-regulating PANX1 via targeting miR-17-5p.

Journal: Journal of molecular histology
Published: 2021
PubMed ID: 34181173
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are available from the corresponding author upon request.
Code availability: -