| Expression pattern: |
UP |
| Associated gene: |
TWIST1 mRNA, TWIST1 |
| Associated microRNA: |
miR-942-5p |
| Biological function: |
Promotes TC cell proliferation, migration, invasion, EMT and tumor growth; knockdown suppresses malignant phenotype and EMT. |
| Molecular mechanism: |
hsa_circ_0001681 acts as a miR-942-5p sponge/ceRNA, competing with TWIST1 mRNA and promoting TWIST1 expression to regulate EMT. |
| Biological pathway or process: |
ceRNA regulation (promotes); EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0001681 is a potential treatment target and potential biomarker in TC treatment. |
| Description: |
hsa_circ_0001681 is up-regulated in thyroid carcinoma tissues and cell lines and is mainly localized in the cytoplasm. It promotes TC cell proliferation, migration, invasion, EMT and xenograft tumor growth by acting as a miR-942-5p sponge to increase TWIST1 expression. The study suggests hsa_circ_0001681 as a potential therapeutic target or biomarker for TC treatment. |
| Confidence score: |
0.6521 |