| Expression pattern: |
UP |
| Associated gene: |
ZEB1 |
| Associated microRNA: |
miR‐665 |
| Biological function: |
Promotes LUAD cell migration, invasion, and metastasis. |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-665 to upregulate ZEB1 expression. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Survival Analysis; ROC Analysis; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
High circ‐TSPAN4 expression is associated with metastatic clinical characteristics and shorter overall survival, and shows prognostic/diagnostic utility by ROC analysis. |
| Description: |
circ-TSPAN4 (hsa_circ_0020732) is up-regulated in LUAD and promotes migration/invasion and in vivo lung metastasis. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-665 to increase ZEB1, linking high circ-TSPAN4 to metastatic features and poor survival. |
| Confidence score: |
0.8066 |