| Expression pattern: |
UP |
| Associated gene: |
Notch1 |
| Associated microRNA: |
miR-326 |
| Biological function: |
Promotes NSCLC cell proliferation and invasion. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-326, thereby increasing Notch1 expression. |
| Biological pathway or process: |
Notch (promotes); proliferation (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot |
| Clinical significance: |
High hsa_circ_0003998 expression was associated with larger tumor size and lymph node metastasis and correlated with shorter overall survival of NSCLC patients. |
| Description: |
hsa_circ_0003998 is upregulated in NSCLC tissues/cell lines and promotes proliferation and invasion. Mechanistically, it sponges miR-326 to relieve repression of Notch1, forming a hsa_circ_0003998/miR-326/Notch1 axis associated with poor prognosis. |
| Confidence score: |
0.7113 |