circRNA basic information
circBase ID: hsa_circ_0072568
Name: hsa_circ_PDE4D
Synonym: circPDE4D
Host Gene: hsa-miR-4306
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal chondrocytes (HNC
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-4306
Biological function: Ectopic expression of circPDE4D rescued cell viability, proliferation, and expressions of B-cell lymphoma/leukemia-2 (Bcl-2) and Collagen type II alpha1 in IL-1beta-insulted HNC, and meanwhile declined apoptosis rate and levels of Bcl-2-associated X protein, cleaved caspase-3, cleaved poly (ADP-ribose) polymerase-1, matrix metalloproteinase-13, ADAM metallopeptidase with thrombospondin type 1 motif 5, IL-6, and IL-8.
Molecular mechanism: CircPDE4D and SOX9 were competing endogenous RNAs (ceRNAs) for hsa-miR-4306, and circPDE4D could positively regulate SOX9 expression via hsa-miR-4306.
Survival: -
Supported No.:
 2
Description:

CircPDE4D and miR-4306 were important regulators in regulating IL-1beta-induced HNC apoptosis and matrix degradation via regulating the key transcription factor SOX9, suggesting a novel circPDE4D/miR-4306/SOX9 ceRNA pathway in OA-related chondrocyte dysfunction.
Other information
Title:

Circular RNA from phosphodiesterase 4D can attenuate chondrocyte apoptosis and matrix degradation under OA milieu induced by IL-1beta via circPDE4D/miR-4306/SOX9 Cascade.

Journal: Immunopharmacol Immunotoxicol
Published: 2022/5/14
PubMed ID: 35549803