| Expression pattern: |
UP |
| Associated gene: |
HMGA1 |
| Associated microRNA: |
miR-324-5p, miR-217 |
| Biological function: |
Promotes gastric cancer cell viability/proliferation and wound healing; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-324-5p, thereby regulating HMGA1 (miR-324-5p/HMGA1 axis). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
hsa_circ_0091994 is up-regulated in gastric cancer tissues and promotes malignant phenotypes. Its knockdown suppresses proliferation/viability, reduces wound healing ability and EMT markers, and increases apoptosis, and it inhibits tumor growth in a cell line-derived xenograft model by repressing the miR-324-5p/HMGA1 axis (ceRNA regulation). |
| Confidence score: |
0.7094 |