circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
10283
Disease MeSH ID:
D011471
Disease NCIt ID:
C7378
Disease ICD11 ID:
-
Disease OMIM ID:
-
Species: Human
Species details: Homo sapiens
Tissue specimen:

prostatic cancer tissue samples; patient-matched adjacent noncancerous tissue samples; prostatic hyperplasia tissues; xenograft tumor tissues

Cell lines:

PC-3; VCaP; DU145; LNCaP; 22Rv1; PWPE-1

In vivo animal model:

cell line-derived xenograft

circRNA-disease information
Expression pattern:
UP
Associated gene: MTDH / metadherin
Associated microRNA: miR-448
Biological function: circHIPK3 promotes PCa cell proliferation, migration, invasion, and tumor growth in vivo.
Molecular mechanism: circHIPK3 acts as a miR-448 sponge to increase MTDH expression and thereby promote prostate cancer progression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other); other pathway/process (promotes)

Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis

Clinical significance:

circHIPK3 may be a potential therapeutic target and promising therapeutic marker for PCa.

Description:

circHIPK3 is upregulated in prostate cancer tissues and cell lines. It promotes PCa cell proliferation, migration, invasion, and xenograft tumor growth by sponging miR-448 and enhancing MTDH expression, suggesting an oncogenic role and potential therapeutic relevance.

Confidence score:

0.7177

Other information
Title:

Circular RNA circHIPK3 modulates prostate cancer progression via targeting miR-448/MTDH signaling.

Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Published: 2021
PubMed ID: 34142340
Study type:

combined biological and clinical study

Data availability: -
Code availability: -