| Expression pattern: |
UP |
| Associated gene: |
MTDH / metadherin |
| Associated microRNA: |
miR-448 |
| Biological function: |
circHIPK3 promotes PCa cell proliferation, migration, invasion, and tumor growth in vivo. |
| Molecular mechanism: |
circHIPK3 acts as a miR-448 sponge to increase MTDH expression and thereby promote prostate cancer progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circHIPK3 may be a potential therapeutic target and promising therapeutic marker for PCa. |
| Description: |
circHIPK3 is upregulated in prostate cancer tissues and cell lines. It promotes PCa cell proliferation, migration, invasion, and xenograft tumor growth by sponging miR-448 and enhancing MTDH expression, suggesting an oncogenic role and potential therapeutic relevance. |
| Confidence score: |
0.7177 |