| Expression pattern: |
UP |
| Associated gene: |
beta-catenin, cyclin D1, C-myc, LEF-1 |
| Associated microRNA: |
miR-383 |
| Biological function: |
promotes proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth and lung metastasis |
| Molecular mechanism: |
circ_0068464 binds (sponges) miR-383 and regulates Wnt/beta-catenin pathway activation, reducing beta-catenin and downstream proteins (Cyclin D1, C-myc, LEF-1). |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; FISH / smFISH; RNase R Treatment; Transfection; MTT; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; H&E Staining; RNA-seq |
| Clinical significance: |
- |
| Description: |
circ_0068464 is up-regulated in colorectal cancer and acts as an oncogenic circRNA. It promotes CRC cell proliferation/migration/invasion and inhibits apoptosis by binding miR-383 and enhancing Wnt/beta-catenin pathway activity, and its knockdown suppresses tumor growth and lung metastasis in vivo. |
| Confidence score: |
0.7396 |