| Expression pattern: |
UP |
| Associated gene: |
mRNAs (41 predicted) |
| Associated microRNA: |
hsa-miR-6785-5p, hsa-miR-1275, hsa-miR-490-3p, hsa-miR-1229-5p, hsa-miR-6088 |
| Biological function: |
Associated with lymph node metastasis; potential diagnostic biomarker and prognostic predictor for PTC. |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA interaction network (bioinformatics). |
| Biological pathway or process: |
ceRNA regulation (other); VEGF/VEGFR (other); Notch (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Higher hsa_circRNA_007148 expression was correlated with lymph node metastasis; ROC AUC 0.846 for distinguishing PTC from normal tissues. |
| Description: |
hsa_circRNA_007148 is up-regulated in PTC tissues and its higher expression is associated with lymph node metastasis. It shows diagnostic potential for distinguishing PTC from adjacent normal thyroid tissues, and was analyzed in a predicted circRNA-miRNA-mRNA network. |
| Confidence score: |
0.6556 |