| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential diagnostic biomarker and staging marker for CRC; higher levels associated with advanced/metastatic disease. |
| Molecular mechanism: |
Not experimentally determined in this study. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Cohort Study |
| Clinical significance: |
Elevated serum circPHLPP2 distinguishes CRC patients from healthy controls and increases with cancer stage; shows diagnostic ability for metastatic vs non-metastatic CRC (AUC 0.722). |
| Description: |
Serum circPHLPP2 is up-regulated in colorectal cancer patients and increases with advancing AJCC stage, with highest levels in metastatic disease. It shows strong diagnostic performance versus healthy controls and has moderate ability to distinguish metastatic from non-metastatic CRC, but no survival association was evaluated. |
| Confidence score: |
0.4758 |