circRNA basic information
circBase ID: hsa_circ_0075503
Name: hsa_circ_SLC22A23
Synonym: circ_0075503
Host Gene: SLC22A23
Genomic location(hg19): chr6:3324067-3416089:-
Genomic location(hg38): chr6:3323833-3415855:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005133
MONDO name: endometriosis
Disease details: endometriosis
Disease DO ID:
 289
Disease MeSH ID:
 D004715
Disease NCIt ID:
 C3014
Disease ICD11 ID:
 1838213761
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

ectopic endometrium; eutopic endometrium
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KLF12, Ago2, RISC
Associated microRNA: miR-15a-5p
Biological function: circ_0075503 promotes E2-induced viability, migration, invasion and epithelial-to-mesenchymal transition marker changes in eutopic endometrial stromal cells; knockdown suppresses these effects.
Molecular mechanism: circ_0075503 acts as a ceRNA by sponging miR-15a-5p to regulate KLF12 expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; MTT; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis
Clinical significance:

Knockdown of circ_0075503 indicates a novel target for the treatment of endometriosis.
Description:

circ_0075503 is up-regulated in ectopic endometrium and ectopic ESCs from endometriosis patients. Functionally, circ_0075503 promotes E2-induced ESC viability, migration, invasion and EMT-like marker changes, while its knockdown suppresses these phenotypes. Mechanistically, circ_0075503 sponges miR-15a-5p to increase KLF12 expression, forming a circ_0075503/miR-15a-5p/KLF12 regulatory axis with potential therapeutic relevance.
Confidence score:

0.7551
Other information
Title:

Knockdown of circ_0075503 suppresses cell migration and invasion by regulating miR-15a-5p and KLF12 in endometriosis.

Journal: Molecular and cellular biochemistry
Published: 2021
PubMed ID: 34117589
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Code availability: -