circRNA basic information
circBase ID: -
Name: hsa_circ_SFMBT2
Synonym: circRNA SFMBT2
Host Gene: SFMBT2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; noncancerous tissue; paracarcinoma tissues
Cell lines:

D54; A172; U251; A735
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: MTSS1
Associated microRNA: miR-182-5p
Biological function: Inhibits proliferation, migration and invasion (metastasis) of glioma cells.
Molecular mechanism: Acts as a miRNA sponge by binding miR-182-5p, thereby restoring MTSS1 expression.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay
Clinical significance:

Low circ_SFMBT2 expression is associated with metastasis and advanced glioma grade.
Description:

circ_SFMBT2 is down-regulated in glioma tissues and cell lines. Functionally, circ_SFMBT2 suppresses glioma cell proliferation and metastasis-related behaviors by binding miR-182-5p and relieving repression of MTSS1 (circ_SFMBT2/miR-182-5p/MTSS1 axis).
Confidence score:

0.6099
Other information
Title:

Circular RNA SFMBT2 Inhibits the Proliferation and Metastasis of Glioma Cells Through Mir-182-5p/Mtss1 Pathway.

Journal: Technology in cancer research & treatment
Published: 2020
PubMed ID: 32729377
Study type:

combined biological and clinical study
Data availability: The data sets generated or analyzed during the present study are included in this published article.
Code availability: -