| Expression pattern: |
DN |
| Associated gene: |
FOSB |
| Associated microRNA: |
miR-184 |
| Biological function: |
Circ_0021087 represses GC cell malignancy by inhibiting proliferation, EMT, migration and invasion, inducing apoptosis, and reducing xenograft tumor growth. |
| Molecular mechanism: |
Circ_0021087 acts as a miR-184 sponge and elevates FOSB expression, thereby repressing malignant behaviours of GC cells. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); EMT (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Circ_0021087 was decreased in GC tissues and may be a promising target for GC treatment. |
| Description: |
In gastric cancer, hsa_circ_0021087/circ_0021087 is down-regulated and functions as a tumor suppressor. It sponges miR-184 to increase FOSB expression, thereby inhibiting proliferation, EMT, migration, invasion and xenograft growth while promoting apoptosis. |
| Confidence score: |
0.7552 |