| Expression pattern: |
UP |
| Associated gene: |
PHF10 |
| Associated microRNA: |
miR-409-3p |
| Biological function: |
promotes proliferation, migration, invasion and tumor growth; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: circ_0001023 sponges miR-409-3p to increase PHF10 expression |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
highly expressed circ_0001023 in tumor tissues was markedly correlated with local lymph node invasion and higher T stage in GC patients |
| Description: |
circ_0001023 is up-regulated in gastric cancer tissues/cells and promotes malignant phenotypes (proliferation, migration/invasion, tumor growth) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA that sponges miR-409-3p, thereby increasing PHF10 expression (circ_0001023/miR-409-3p/PHF10 axis). |
| Confidence score: |
0.6285 |