| Expression pattern: |
UP |
| Associated gene: |
CCND3 |
| Associated microRNA: |
miR-34a |
| Biological function: |
CircMYLK promotes bladder cancer cell growth, migration, invasion, and survival; circMYLK downregulation induces cell cycle arrest and apoptosis and suppresses migration and invasion. |
| Molecular mechanism: |
CircMYLK acts as a competing endogenous RNA by binding miR-34a, thereby upregulating CCND3 expression in bladder cancer cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot |
| Clinical significance: |
CircMYLK expression was associated with clinicopathological features including tumor size, TNM stage, and lymphatic metastasis; circMYLK was proposed as a promising biomarker for bladder cancer treatment. |
| Description: |
CircMYLK/circ_0067049 is up-regulated in human bladder cancer tissues and cell lines. It promotes malignant bladder cancer cell behaviors, including growth, migration, invasion, and survival, while inhibiting apoptosis and cell cycle arrest. Mechanistically, cytoplasmic circMYLK competitively binds miR-34a and increases CCND3 expression through a ceRNA regulatory network. |
| Confidence score: |
0.7283 |