| Expression pattern: |
DN |
| Associated gene: |
ERBB3, PXN, INSR, STK4, TRAPPC6A, ADCY5, NFATC2, KAT2B |
| Associated microRNA: |
miR-1200, miR-1263, miR-1290, miR-576-5p, miR-633 |
| Biological function: |
circMYBL1 increases osimertinib sensitivity in NSCLC cells; reduced circMYBL1 expression facilitates proliferation, migration, and invasion under osimertinib treatment. |
| Molecular mechanism: |
Potential ceRNA mechanism involving circMYBL1-miRNA-mRNA interaction networks; circMYBL1 may act as a miRNA sponge and affect target mRNAs and enriched pathways related to cancer progression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); drug resistance (inhibits); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Bioinformatics Analysis |
| Clinical significance: |
CircMYBL1 may be a novel molecular biomarker and therapeutic target for osimertinib-resistant NSCLC. |
| Description: |
circMYBL1/hsa_circ_0136924 is downregulated in osimertinib-resistant NSCLC cell lines and in plasma from osimertinib-resistant NSCLC patients. Knockdown of circMYBL1 reduces osimertinib sensitivity and increases NSCLC cell survival, migration, and invasion, suggesting a suppressive role in acquired osimertinib resistance. The proposed mechanism is a potential cytoplasmic circMYBL1-miRNA-mRNA ceRNA network involving predicted miRNAs and target mRNAs. |
| Confidence score: |
0.7514 |