| Expression pattern: |
UP |
| Associated gene: |
FOSL2, Ago2 |
| Associated microRNA: |
miR-766-3p |
| Biological function: |
promotes proliferation, migration and invasion; promotes tumor growth in vivo |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) binding miR-766-3p to relieve miR-766-3p-mediated repression of FOSL2. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; TUNEL; IHC (Immunohistochemistry); ROC Analysis; Survival Analysis; Clinical Sample Validation |
| Clinical significance: |
Diagnostic value (ROC AUC=0.8742) and prognostic association: patients with reduced hsa_circ_0056836 had longer overall survival; proposed tumor biomarker. |
| Description: |
hsa_circ_0056836 is up-regulated in HCC tissues and cell lines and acts as an oncogenic circRNA. It predominantly localizes to the cytoplasm and sponges miR-766-3p to increase FOSL2, promoting proliferation, migration/invasion and xenograft tumor growth. High expression is associated with worse overall survival and shows diagnostic potential by ROC analysis. |
| Confidence score: |
0.8015 |