circRNA basic information
circBase ID: hsa_circ_0082002
Name: hsa_circ_MET
Synonym: chr7: 116699071-116700284+
Host Gene: MET
Genomic location(hg19): chr7:116339124-116340338:+
Genomic location(hg38): chr7:116699070-116700284:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: Papillary thyroid carcinoma
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PTC tissue; neighboring non-tumor tissues
Cell lines:

TPC1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: potential diagnostic biomarker for PTC; increased stability vs mRNA
Molecular mechanism: higher stability under RNase R and temperature; predicted ceRNA network involvement
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

effective diagnostic indicator; potential biomarker for the diagnosis of PTC
Description:

chr7: 116699071-116700284+ (hsa_circ_0082002; host gene MET) is up-regulated in papillary thyroid carcinoma and performs well as a diagnostic marker in ROC analyses after RT-qPCR validation. It was additionally used for stability testing in TPC1 cells, showing higher tolerance to RNase R, temperature, and time compared with linear mRNA; mechanistic ceRNA interactions were only computationally predicted.
Confidence score:

0.7113
Other information
Title:

Expression Profiles of Circular RNAs in Human Papillary Thyroid Carcinoma Based on RNA Deep Sequencing.

Journal: OncoTargets and therapy
Published: 2021
PubMed ID: 34188490
Study type:

combined biological and clinical study
Data availability: GSE171011
Code availability: -