| Expression pattern: |
DN |
| Associated gene: |
TFCP2, Ago2 |
| Associated microRNA: |
miR-660 |
| Biological function: |
suppresses melanoma cell proliferation and metastasis |
| Molecular mechanism: |
circITCH acts as a ceRNA by sponging miR-660, relieving repression of TFCP2; recruitment to Ago2-related RISC supports miRNA-mediated regulation |
| Biological pathway or process: |
proliferation (inhibits); metastasis (inhibits); ceRNA regulation (other); migration (inhibits); invasion (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
circITCH can be a diagnostic biomarker as well as a target for treating melanoma |
| Description: |
circITCH is down-regulated in melanoma tissues and acts as a tumor suppressor by inhibiting melanoma cell proliferation and metastasis. Mechanistically, circITCH predominantly localizes in the cytoplasm and functions as a ceRNA to sponge miR-660, thereby upregulating TFCP2 via an Ago2/RISC-associated interaction. |
| Confidence score: |
0.7295 |