| Expression pattern: |
DN |
| Associated gene: |
PTEN, AKT, pAKT |
| Associated microRNA: |
miR-21-5p, miR-942-5p |
| Biological function: |
Suppresses colorectal cancer cell proliferation, migration, invasion and tumour growth, promotes apoptosis, and inhibits PTEN/AKT signalling pathway activity. |
| Molecular mechanism: |
Exosomal circEPB41L2 acts as a sponge for miR-21-5p and miR-942-5p, thereby regulating PTEN/AKT signalling pathway activity to repress colorectal cancer progression. |
| Biological pathway or process: |
PI3K/AKT (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Exosomal circEPB41L2 showed diagnostic value for colorectal cancer and tumour stage, and its expression was associated with lymph node metastasis. |
| Description: |
Exosomal circEPB41L2 is downregulated in plasma exosomes from colorectal cancer patients and in colorectal cancer cells. It functions as a tumour suppressor by sponging miR-21-5p and miR-942-5p, increasing PTEN and inhibiting AKT activation, thereby reducing proliferation, migration, invasion and tumour growth while promoting apoptosis. It also showed potential diagnostic value for colorectal cancer and tumour staging. |
| Confidence score: |
0.8325 |