circRNA basic information
circBase ID: hsa_circ_0000517
Name: -
Synonym: circular RNA_0000517
Host Gene: -
Genomic location(hg19): chr14:20811404-20811492:-
Genomic location(hg38): chr14:20343245-20343333:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; paired adjacent tissue; HCC tissue; normal adjacent tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Upregulated in HCC tumor tissue; showed diagnostic value only as part of a combined three-circRNA ROC model; not correlated with clinicopathological characteristics or overall survival in this study.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis
Clinical significance:

Upregulated in tumor tissue; not correlated with clinicopathological characteristics or OS, but included in a combined circRNA ROC model that differentiated tumor tissue from paired adjacent tissue.
Description:

This study found that circ_0000517 is upregulated in HCC tumor tissue compared with paired adjacent tissue. Unlike circ_0004913, circ_0000517 was not associated with clinicopathological characteristics or OS in the reported analyses, although it contributed to a combined three-circRNA tissue-discrimination ROC model.
Confidence score:

0.5918
Other information
Title:

Dysregulated circ_0004913, circ_0008160, circ_0000517, and their potential as biomarkers for disease monitoring and prognosis in hepatocellular carcinoma.

Journal: Journal of clinical laboratory analysis
Published: 2021
PubMed ID: 34018640
Study type:

clinical study
Data availability: The data that supports the findings of this study are available in this article.
Code availability: -