| Expression pattern: |
UP |
| Associated gene: |
mTOR |
| Associated microRNA: |
miR-634, miR-455-3p, miR-195-5P |
| Biological function: |
circTPCN promotes cervical cancer cell proliferation, migration and invasion, and inhibits apoptosis; knockdown of circTPCN suppresses proliferation, migration and invasion and increases apoptosis. |
| Molecular mechanism: |
circTPCN acts as a ceRNA/molecular sponge of miR-634 to enhance mTOR expression, forming the circTPCN/miR-634/mTOR regulatory pathway. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other); PI3K/AKT/mTOR (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay |
| Clinical significance: |
circTPCN represents a potential biomarker and potential therapeutic target for cervical cancer. |
| Description: |
circTPCN is significantly up-regulated in cervical cancer samples and may serve as a biomarker. Functionally, circTPCN promotes cervical cancer cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, it acts mainly as a miR-634 sponge to enhance mTOR expression, forming a circTPCN/miR-634/mTOR regulatory pathway. |
| Confidence score: |
0.6777 |