circRNA basic information
circBase ID: hsa_circ_0066966
Name: hsa_circ_GOLGB1
Synonym: -
Host Gene: GOLGB1
Genomic location(hg19): chr3:121441108-121448187:-
Genomic location(hg38): chr3:121722261-121729340:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: HBV-positive liver cancer
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HepG2.2.15; Hep3B; HepG2; Huh7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-214-3p, hsa-miR-922, hsa-miR-646, hsa-miR-3619-5p, hsa-miR-374a-3p
Biological function: Promotes proliferation and migration of HBV-positive liver cancer cells
Molecular mechanism: Predicted ceRNA (miRNA sponge) mechanism via MREs (bioinformatics prediction); mechanism not experimentally validated
Biological pathway or process:

proliferation (promotes); migration (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis; Transfection; MTT; Transwell Assay
Clinical significance:

-
Description:

hsa_circ_0066966 is up-regulated in HBV-positive liver cancer cell lines and promotes cell proliferation and migration. Its interaction with multiple miRNAs (e.g., hsa-miR-3619-5p, hsa-miR-214-3p, hsa-miR-646) was predicted bioinformatically, but downstream targets/pathways were not experimentally confirmed.
Confidence score:

0.4852
Other information
Title:

Role of hsa_circ_0066966 in proliferation and migration of hepatitis B virus-related liver cancer cells.

Journal: Experimental and therapeutic medicine
Published: 2022
PubMed ID: 34976133
Study type:

biological research
Data availability: GSE181988
Code availability: -