circRNA basic information
circBase ID: hsa_circ_0091579
Name: hsa_circ_GPC3
Synonym: circ_0091579
Host Gene: GPC3
Genomic location(hg19): chrX:132795757-132888203:-
Genomic location(hg38): chrX:133661729-133754176:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissue samples; neighboring noncancerous liver tissue samples
Cell lines:

MIHA; Hep3B; MHCC97-H; Huh7; 293T; C3A
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: H3F3B
Associated microRNA: miR-624
Biological function: Facilitates the Warburg effect, migration, invasion, malignant behaviors, and xenograft tumor growth of HCC cells; inhibits apoptosis.
Molecular mechanism: circ_0091579 functions as a cytoplasmic ceRNA/miRNA sponge for miR-624, thereby upregulating H3F3B expression and promoting the Warburg effect and malignant behaviors in HCC cells.
Biological pathway or process:

glycolysis (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0091579/circ_0091579 is upregulated in HCC tissues and cells and acts as an oncogenic circRNA. Mechanistically, it sponges miR-624 to increase H3F3B expression, thereby promoting the Warburg effect, migration, invasion, malignant behavior, and xenograft tumor growth while suppressing apoptosis.
Confidence score:

0.7295
Other information
Title:

Circular RNA hsa_circ_0091579 facilitates the Warburg effect and malignancy of hepatocellular carcinoma cells via the miR-624/H3F3B axis.

Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Published: 2021
PubMed ID: 33934291
Study type:

combined biological and clinical study
Data availability: Supplementary File 1; https:// doi. org/ 10. 1007/ s12094-021-02627-4
Code availability: -