circRNA basic information
circBase ID: hsa_circ_0005320
Name: hsa_circ_SEPT9
Synonym: Circular RNA (circRNA) septin 9
Host Gene: SEPT9
Genomic location(hg19): chr17:75398140-75398785:+
Genomic location(hg38): chr17:77402058-77402703:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

glioma tissues; traumatic brain tissue samples; normal tissues; resected tumor tissues
Cell lines:

A172; T98G; LN229; LN18; LN382; CAS1; DBTRG; NHA
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: LASP1, LIM and SH3 protein 1, AGO2, HIF-1alpha, HK2, LDHA, MMP2, MMP9
Associated microRNA: miR-432-5p
Biological function: CircSEPT9 promotes glioma cell proliferation, cell cycle progression, migration, invasion, glycolytic metabolism, and xenograft tumor growth, while suppressing apoptosis.
Molecular mechanism: CircSEPT9 acts as a miR-432-5p sponge to up-regulate LASP1 expression, thereby promoting malignant behaviors of glioma cells.
Biological pathway or process:

proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); In Vivo Animal Model
Clinical significance:

CircSEPT9 is highly expressed in glioma tissues and may provide new potential therapeutic targets for glioma.
Description:

CircSEPT9 (hsa_circ_0005320) is up-regulated in glioma tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-432-5p and thereby increasing LASP1 expression, promoting proliferation, migration, invasion, glycolysis, cell cycle progression, and xenograft tumor growth while inhibiting apoptosis.
Confidence score:

0.7795
Other information
Title:

CircRNA SEPT9 contributes to malignant behaviors of glioma cells via miR-432-5p-mediated regulation of LASP1.

Journal: Brain research
Published: 2021
PubMed ID: 33915163
Study type:

combined biological and clinical study
Data availability: Supplementary data to this article can be found online at https://doi.
Code availability: -