| Expression pattern: |
UP |
| Associated gene: |
PLAGL2, Ago2, CTNNB1 (beta-catenin), CCND1, CDK2, c-MYC, MMP2 |
| Associated microRNA: |
miR-1270 |
| Biological function: |
promotes LUAD cell proliferation, invasion and migration; promotes tumor growth in vivo |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-1270 to upregulate PLAGL2, thereby activating WNT signaling (Wnt/beta-catenin) in LUAD. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
Circ-SOX4 is up-regulated in LUAD tissues and cell lines and promotes proliferation, invasion, migration, and xenograft tumor growth. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-1270 to de-repress PLAGL2, activating Wnt/beta-catenin signaling and EMT-related changes. |
| Confidence score: |
0.807 |