| Expression pattern: |
UP |
| Associated gene: |
TRPM7 |
| Associated microRNA: |
miR-218-5p |
| Biological function: |
promotes LSCC cell proliferation, invasion, migration, tumor growth and metastasis |
| Molecular mechanism: |
ceRNA (miRNA sponge) mechanism: hsa_circ_0023305 sponges miR-218-5p to upregulate TRPM7 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining |
| Clinical significance: |
High hsa_circ_0023305 expression correlates with advanced TNM stage, lymph node metastasis, and poor overall survival in LSCC patients |
| Description: |
hsa_circ_0023305 is up-regulated in LSCC tissues and promotes proliferation, migration/invasion and metastasis. Mechanistically, it acts as a sponge for miR-218-5p, thereby relieving repression of TRPM7 and enhancing LSCC progression, and its high expression associates with poor overall survival. |
| Confidence score: |
0.7631 |