| Expression pattern: |
UP |
| Associated gene: |
NRF1, HMGA1, beta-catenin |
| Associated microRNA: |
- |
| Biological function: |
Promotes lymphoma cell proliferation, migration and invasion; functions as an oncogene in lymphoma progression. |
| Molecular mechanism: |
NRF1 transcriptionally regulates circNSUN2; circNSUN2 stabilizes HMGA1 by binding the HMGA1 3 UTR and activates the Wnt/beta-catenin signaling pathway. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); mRNA stability (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; RNA Pull-Down; ChIP / ChIP-seq; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circNSUN2 knockdown could be used in the treatment of lymphoma. |
| Description: |
circNSUN2 is up-regulated in malignant lymphoma tissues and lymphoma cell lines. It promotes lymphoma cell proliferation, migration and invasion, and its expression is regulated by the transcription factor NRF1. Mechanistically, circNSUN2 stabilizes HMGA1 by binding the HMGA1 3 UTR, thereby activating the Wnt/beta-catenin signaling pathway. |
| Confidence score: |
0.8324 |