| Expression pattern: |
DN |
| Associated gene: |
SOX7 |
| Associated microRNA: |
miR-155 |
| Biological function: |
CircUBQLN1 promotes proliferation and inhibits apoptosis and oxidative stress, thereby alleviating Mg2+-free-induced nerve injury in HN-h epilepsy cell model. |
| Molecular mechanism: |
CircUBQLN1 acts as a miR-155 sponge to upregulate SOX7 expression through a circUBQLN1/miR-155/SOX7 ceRNA axis. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); other pathway/process (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
CircUBQLN1 might be used as a biomolecular target or therapeutic target for the treatment of epilepsy. |
| Description: |
CircUBQLN1 is downregulated in TLE tissues and Mg2+-free-treated human hippocampal neurons. Its overexpression protects HN-h cells from epilepsy-like injury by promoting proliferation and reducing apoptosis and oxidative stress. Mechanistically, circUBQLN1 functions as a cytoplasmic miR-155 sponge to increase SOX7 expression, forming the circUBQLN1/miR-155/SOX7 regulatory axis. |
| Confidence score: |
0.7759 |