circRNA basic information
circBase ID: hsa_circ_0061395
Name: hsa_circ_BACH1
Synonym: circBACH1
Host Gene: BACH1
Genomic location(hg19): chr21:30698379-30702014:+
Genomic location(hg38): chr21:29326058-29329693:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; surrounding normal liver tissues; xenograft tumors
Cell lines:

Huh-7; SNU-387; HCCLM3; THLE-2
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: SERBP1
Associated microRNA: miR-656-3p, miR-656e3p
Biological function: circBACH1 facilitates HCC progression by promoting proliferation, migration, invasion, EMT and tumor growth, and by inhibiting apoptosis.
Molecular mechanism: circBACH1 acts as a ceRNA by sponging miR-656e3p to increase SERBP1 expression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits)
Detected method:
Q
Validation methods:

RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model
Clinical significance:

-
Description:

circBACH1 (hsa_circ_0061395) is up-regulated in HCC tissues and cell lines. It promotes HCC cell proliferation, migration, invasion, EMT and xenograft tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic circBACH1 functions as a ceRNA that sponges miR-656-3p/miR-656e3p to increase SERBP1 expression.
Confidence score:

0.7635
Other information
Title:

CircRNA circBACH1 (hsa_circ_0061395) serves as a miR-656-3p sponge to facilitate hepatocellular carcinoma progression through increasing SERBP1 expression.

Journal: Biochemical and biophysical research communications
Published: 2021
PubMed ID: 33831787
Study type:

combined biological and clinical study
Data availability: Supplementary data to this article can be found online at https://doi.org/10.1016/j.bbrc.2021.03.136.
Code availability: -