| Expression pattern: |
UP |
| Associated gene: |
LRIG1 |
| Associated microRNA: |
miR-126-5p |
| Biological function: |
Acts as a circulating biomarker of AKI and predicts 28-day mortality; potentially functions as a miRNA sponge. |
| Molecular mechanism: |
Predicted ceRNA/miRNA sponge interaction with miR-126-5p based on bioinformatic target prediction; downstream effects not experimentally proven in this study. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Agarose Gel Electrophoresis; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Baseline circulating ciRs-126 was increased in nonsurvivors and was an independent predictor of 28-day survival; ROC AUC 0.92. |
| Description: |
In critically ill AKI patients at initiation of RRT, circulating ciRs-126 (hsa_circ_0003266) is significantly increased and is an independent predictor of 28-day mortality. It is predicted to sponge miR-126-5p based on bioinformatic target prediction, but direct binding was not definitively proven. |
| Confidence score: |
0.7278 |