| Expression pattern: |
DN |
| Associated gene: |
SIRT1 |
| Associated microRNA: |
miR-375 |
| Biological function: |
Alleviates IL-1beta-induced chondrocyte injuries by increasing cell viability and reducing apoptosis, inflammatory responses, and ECM degradation. |
| Molecular mechanism: |
circ_0001103 acts as a miR-375 sponge to upregulate SIRT1 expression, thereby ameliorating IL-1beta-induced chondrocyte injuries. |
| Biological pathway or process: |
apoptosis (inhibits); inflammation (inhibits); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
circ_0001103 was proposed as a promising biomarker in OA pathogenesis, and decreased serum expression might have clinical indication significance in OA. |
| Description: |
circ_0001103 is downregulated in OA cartilage tissues, OA serum samples, and IL-1beta-treated human chondrocytes. Its overexpression protects chondrocytes from IL-1beta-induced injury by inhibiting apoptosis, inflammation, and ECM degradation. Mechanistically, circ_0001103 sponges miR-375 to increase SIRT1 expression, suggesting potential biomarker value in OA pathogenesis. |
| Confidence score: |
0.7759 |