| Expression pattern: |
UP |
| Associated gene: |
ZFX |
| Associated microRNA: |
miR-142-3p |
| Biological function: |
promotes NSCLC cell proliferation, migration and invasion; inhibits apoptosis; promotes tumorigenesis in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0020123 sponges miR-142-3p to upregulate ZFX |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model |
| Clinical significance: |
high circ_0020123 expression is related to poor prognosis of NSCLC patients; considered a biomarker for NSCLC diagnosis and treatment |
| Description: |
circ_0020123 is up-regulated in NSCLC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration/invasion and tumorigenesis while inhibiting apoptosis, mainly by sponging miR-142-3p to increase ZFX expression (miR-142-3p/ZFX axis). |
| Confidence score: |
0.6831 |