| Expression pattern: |
UP |
| Associated gene: |
SLC38A1, Ago2 |
| Associated microRNA: |
miR-485-5p |
| Biological function: |
CircRUNX1 promotes CRC cell colony formation, migration, invasion, tumour growth and glutamine metabolism, and inhibits apoptosis. |
| Molecular mechanism: |
CircRUNX1 acts as a miR-485-5p sponge to elevate SLC38A1 expression, thereby promoting CRC progression and glutamine metabolism. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); glutaminolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circRUNX1 level was related to lymph node metastasis, TNM stages and tumour stages, and may be a potential biomarker for CRC prognosis. |
| Description: |
circRUNX1 is up-regulated in colorectal cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes CRC cell colony formation, migration, invasion, tumour growth and glutamine metabolism while suppressing apoptosis through the circRUNX1/miR-485-5p/SLC38A1 axis. Its expression is associated with lymph node metastasis and TNM stage, suggesting potential prognostic biomarker value. |
| Confidence score: |
0.7595 |