| Expression pattern: |
UP |
| Associated gene: |
KPNB1 |
| Associated microRNA: |
miR-584-5p |
| Biological function: |
Promotes proliferation, angiogenesis, migration, invasion, cell cycle progression, and tumor growth in glioblastoma cells. |
| Molecular mechanism: |
circPITX1 functions as a competing endogenous RNA that sponges miR-584-5p to regulate KPNB1 expression in GBM. |
| Biological pathway or process: |
proliferation (promotes); angiogenesis (promotes); migration (promotes); invasion (promotes); cell cycle (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circPITX1/miR-584-5p/KPNB1 could serve as diagnostic markers for GBM patients. |
| Description: |
circPITX1 is up-regulated in glioblastoma tissues and cells and acts as an oncogenic circRNA. It promotes GBM cell proliferation, angiogenesis, migration, invasion, cell cycle progression, and xenograft tumor growth by sponging miR-584-5p and regulating KPNB1 expression. The study suggests the circPITX1/miR-584-5p/KPNB1 axis may have diagnostic relevance for GBM patients. |
| Confidence score: |
0.8511 |