| Expression pattern: |
UP |
| Associated gene: |
EIF4A3, IGFBP3 |
| Associated microRNA: |
- |
| Biological function: |
circMETTL9 promotes airway inflammation, airway remodeling, abnormal proliferation, apoptosis, and oxidative stress in airway epithelial cells; aerobic exercise reduces circMETTL9 expression and thereby exerts protective anti-inflammatory, anti-proliferative, anti-apoptotic, and antioxidative effects. |
| Molecular mechanism: |
circMETTL9 binds the RNA-binding protein EIF4A3 and inhibits IGFBP3 transcription and translation; EIF4A3 positively regulates IGFBP3 mRNA and protein expression, and IGFBP3 mediates circMETTL9 effects on proliferation, apoptosis, and oxidative stress. |
| Biological pathway or process: |
inflammation (promotes); proliferation (promotes); apoptosis (promotes); fibrosis (promotes); p53 signaling (other); other pathway/process (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
FISH / smFISH; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; EdU Staining; TUNEL; IF (Immunofluorescence); In Vivo Animal Model; H&E Staining; ELISA; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circMETTL9 is proposed as a potential therapeutic target for treating chronic allergic lung inflammation and asthma management. |
| Description: |
circMETTL9 is up-regulated in chronic allergic airway inflammation/asthma models and is reduced by aerobic exercise. Functionally, circMETTL9 promotes airway inflammation/remodeling and increases airway epithelial cell proliferation, apoptosis, and oxidative stress. Mechanistically, circMETTL9 binds EIF4A3 and inhibits IGFBP3 transcription and translation, forming a circMETTL9/EIF4A3/IGFBP3 axis that mediates the protective effects of aerobic exercise. |
| Confidence score: |
0.7302 |