circRNA basic information
circBase ID: hsa_circ_0001998
Name: hsa_circ_FUT8
Synonym: Circ_0001998
Host Gene: FUT8
Genomic location(hg19): chr14:65922338-66028484:+
Genomic location(hg38): chr14:65455620-65561766:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

BEAS-2B; HCC827; H460; H1975; A549; H1299
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-145
Biological function: promotes viability, proliferation and invasion and inhibits apoptosis of LUAD cells
Molecular mechanism: acts as a miRNA sponge (ceRNA) for miR-145; rescue by miR-145 inhibitor
Biological pathway or process:

proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Bioinformatics Analysis; RT-qPCR; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; In Vivo Animal Model; Microarray
Clinical significance:

-
Description:

circ_0001998 is upregulated in LUAD cell lines and promotes malignant phenotypes. Knockdown of circ_0001998 inhibits viability/proliferation/invasion and increases apoptosis, at least partly by sponging miR-145 (validated by luciferase and rescue with miR-145 inhibitor).
Confidence score:

0.6004
Other information
Title:

Circ_0001998 Regulates the Proliferation, Invasion, and Apoptosis of Lung Adenocarcinoma via Sponging miR-145.

Journal: Evidence-based complementary and alternative medicine : eCAM
Published: 2022
PubMed ID: 35600959
Study type:

combined biological and clinical study
Data availability: GSE112214; GSE101586; GSE74190; GSE63805
Code availability: -