| Expression pattern: |
UP |
| Associated gene: |
REV3L |
| Associated microRNA: |
miR-433-3p |
| Biological function: |
Circ_0023984 promotes ESCC cell proliferation, colony formation, migration, invasion, tumorigenesis and xenograft tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
Circ_0023984 functions as a ceRNA sponge for miR-433-3p and positively regulates REV3L expression through the miR-433-3p/REV3L axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Circ_0023984 may be a promising therapeutic target for ESCC. |
| Description: |
Circ_0023984 is up-regulated in ESCC tissues and cells and acts as an oncogenic circRNA. It promotes ESCC cell proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-433-3p to increase REV3L expression. The study suggests circ_0023984 as a potential therapeutic target for ESCC. |
| Confidence score: |
0.84 |