circRNA basic information
circBase ID: -
Name: hsa_circ_RTN4
Synonym: RTN4 / chr2:55209651-55214834 / circRTN4
Host Gene: RTN4
Genomic location(hg19): chr2:55209651-55214834:.
Genomic location(hg38): chr2:54982515-54987698:.
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

DLD-1; DKO-1; DKs-8; HCT116; HKe3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: KRAS
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR
Clinical significance:

-
Description:

The RTN4-derived circRNA shows context-dependent changes: it is reduced in KRAS-mutant DLD-1 cells relative to KRAS WT controls but increased in DLD-1-derived exosomes, indicating dysregulated cellular vs exosomal distribution/abundance associated with KRAS mutation status.
Confidence score:

0.3401
Other information
Title:

Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.

Journal: Scientific reports
Published: 2016
PubMed ID: 27892494
Study type:

biological research
Data availability: -
Code availability: -