| Expression pattern: |
UP |
| Associated gene: |
NOL4L |
| Associated microRNA: |
miR-362-5p |
| Biological function: |
circPDE5A promotes NB cell proliferation, migration, invasion, glycolysis and tumour growth; silencing circPDE5A suppresses these malignant phenotypes. |
| Molecular mechanism: |
circPDE5A acts as a miR-362-5p sponge and regulates NOL4L expression through the miR-362-5p/NOL4L axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circPDE5A may be a potential target for NB management. |
| Description: |
circPDE5A is up-regulated in neuroblastoma tissues and cell lines. It promotes NB malignant progression, including proliferation, migration, invasion, glycolysis and in vivo tumour growth, by sponging miR-362-5p and thereby regulating NOL4L expression. The study suggests circPDE5A as a potential therapeutic target for NB management. |
| Confidence score: |
0.7759 |