| Expression pattern: |
DN |
| Associated gene: |
PGC |
| Associated microRNA: |
hsa-let-7c |
| Biological function: |
May act as a ceRNA/miRNA sponge in GC and is associated with pericarcinoma inflammatory cell infiltration and lymphatic metastasis. |
| Molecular mechanism: |
ceRNA mechanism via binding (sponging) hsa-let-7c, affecting PGC down-regulation in GC tissue. |
| Biological pathway or process: |
ceRNA regulation (other); immune regulation (other); metastasis (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
Expression level correlated with pericarcinoma inflammatory cell infiltration and lymphatic metastasis; no significant association with overall survival. |
| Description: |
hsa_circ_0001483 is down-regulated in gastric cancer tissue and binds hsa-let-7c. It is part of a proposed PGC-related ceRNA axis (hsa_circ_0001483-hsa-let-7c-PGC) that may contribute to PGC down-regulation, and its expression is associated with inflammatory cell infiltration and lymphatic metastasis. |
| Confidence score: |
0.4685 |