circRNA basic information
circBase ID: hsa_circ_0129276
Name: hsa_circ_KIF2A
Synonym: CircKIF2A
Host Gene: KIF2A
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005072
MONDO name: neuroblastoma
Disease details: neuroblastoma
Disease DO ID:
 769
Disease MeSH ID:
 D009447
Disease NCIt ID:
 C3270
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NB tissue specimens; adjacent non-tumor tissue specimens; harvested tumors
Cell lines:

SK-N-SH; SK-N-AS; HUVECs
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: PLK4, KIF2A, MMP2, MMP9
Associated microRNA: miR-129-5p
Biological function: CircKIF2A promotes NB cell proliferation, migration, invasion, glycolysis and tumorigenesis; circKIF2A knockdown suppresses these malignant phenotypes.
Molecular mechanism: CircKIF2A acts as a ceRNA sponge for miR-129-5p, thereby positively regulating PLK4 expression and promoting neuroblastoma progression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Transfection; MTT; Transwell Assay; Western Blot; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; In Vivo Animal Model
Clinical significance:

CircKIF2A may be a promising effective target for NB therapy.
Description:

CircKIF2A is up-regulated in neuroblastoma tissues and cell lines. It promotes NB cell proliferation, migration, invasion, glycolysis and in vivo tumor growth by sponging miR-129-5p and increasing PLK4 expression. The study suggests circKIF2A as a potential therapeutic target for NB.
Confidence score:

0.7936
Other information
Title:

CircKIF2A contributes to cell proliferation, migration, invasion and glycolysis in human neuroblastoma by regulating miR-129-5p/PLK4 axis.

Journal: Molecular and cellular biochemistry
Published: 2021
PubMed ID: 33630225
Study type:

combined biological and clinical study
Data availability: All data generated or analyzed during this study are included in this article; supplementary material available at https ://doi.org/10.1007/s1101 0-021-04096 -3
Code availability: -