| Expression pattern: |
UP |
| Associated gene: |
CUL4B, Ago2 |
| Associated microRNA: |
miR-942-5p |
| Biological function: |
promotes proliferation, migration and invasion and inhibits apoptosis of ovarian cancer cells; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0015756 sponges miR-942-5p to up-regulate CUL4B |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
potential therapeutic target for ovarian cancer |
| Description: |
circ_0015756 is up-regulated in ovarian cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes OC cell proliferation, migration and invasion and inhibits apoptosis by sponging miR-942-5p to increase CUL4B expression, and its knockdown suppresses tumor growth in a xenograft model. |
| Confidence score: |
0.7294 |