| Expression pattern: |
UP |
| Associated gene: |
Ago2 |
| Associated microRNA: |
- |
| Biological function: |
promotes cell transformation (anchorage-independent growth); promotes proliferation (trend) |
| Molecular mechanism: |
Interacts with Ago2, suggesting miRNA-associated regulation/sponging potential; oncogenic transformation supported by overexpression. |
| Biological pathway or process: |
proliferation (other); ceRNA regulation (other) |
| Detected method: |
Q
S
M
|
| Validation methods: |
Microarray; RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Transfection; Colony Formation Assay; CCK8; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High expression is significantly associated with poorer overall survival; shows ROC performance distinguishing tumor grades and tumor vs non-tumorous tissue. |
| Description: |
circRaly is up-regulated in HCC, linked to higher tumor grade, and high expression is associated with poorer overall survival. Functionally, its overexpression promotes anchorage-independent growth and shows a non-significant trend toward increased proliferation; it interacts with Ago2 suggesting miRNA-related regulation. |
| Confidence score: |
0.8513 |