| Expression pattern: |
DN |
| Associated gene: |
RGS4 |
| Associated microRNA: |
miR-653-3p |
| Biological function: |
Inhibits CRC cell proliferation, colony formation, migration and wound healing; suppresses EMT-associated motility. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-653-3p, relieving repression of downstream target RGS4; affects EMT marker expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); EMT (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
May serve as a diagnostic and prognostic factor for CRC. |
| Description: |
circWDR78 is down-regulated in colorectal cancer and functions as a tumor suppressor by inhibiting proliferation and motility/EMT-related migration. Mechanistically, it acts as a ceRNA that sponges miR-653-3p to relieve repression of RGS4, forming a circWDR78/miR-653-3p/RGS4 regulatory axis. |
| Confidence score: |
0.8138 |