| Expression pattern: |
UP |
| Associated gene: |
CREBRF, Ago2 |
| Associated microRNA: |
miR-4465 |
| Biological function: |
circ_0102171 promotes cervical cancer cell proliferation, migration, invasion and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0102171 acts as a cytoplasmic ceRNA sponge for miR-4465, thereby enhancing CREBRF expression to aggravate cervical cancer progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circ_0102171 is highly expressed in CC tissues and may be a potential therapeutic target for cervical cancer. |
| Description: |
hsa_circ_0102171 is up-regulated in cervical cancer tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-4465 and increasing CREBRF expression, thereby promoting proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis. |
| Confidence score: |
0.8442 |