circRNA basic information
circBase ID: hsa_circ_0001438
Name: hsa_circ_LARP1B
Synonym: -
Host Gene: LARP1B
Genomic location(hg19): chr4:128995614-128999117:+
Genomic location(hg38): chr4:128074459-128077962:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary HCC tissues; adjacent normal tissues; normal hepatocytes
Cell lines:

HepG2; JHH-4; JHH-5
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential biomarker for the specific diagnosis of HCC, including possible utility for early-stage or nonviral HCC diagnosis.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; RNA-seq; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Potential diagnostic biomarker for HCC; ROC AUC value was 0.941.
Description:

hsa_circ_0001438 was identified from public RNA-seq data as downregulated in primary HCC tissues and was further confirmed by RT-qPCR to be lower in HCC cell lines than in normal hepatocytes. The study proposes hsa_circ_0001438 as a potential diagnostic biomarker for HCC, especially early-stage or nonviral HCC.
Confidence score:

0.6193
Other information
Title:

Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated, respectively, in hepatocellular carcinoma.

Journal: International journal of experimental pathology
Published: 2022
PubMed ID: 36153641
Study type:

combined bioinformatics and biological research
Data availability: GSE77509; CIRCpedia v2
Code availability: -