circRNA basic information
circBase ID: hsa_circ_0008194
Name: hsa_circ_AHNAK
Synonym: -
Host Gene: AHNAK
Genomic location(hg19): chr11:62303416-62304039:-
Genomic location(hg38): chr11:62535944-62536567:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; matched normal tissues
Cell lines:

Hep3B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: AHNAK, AGO2
Associated microRNA: miR-190a
Biological function: promotes cell invasion and metastasis; promotes EMT
Molecular mechanism: ceRNA sponge mechanism: circ_0008194 binds miR-190a to relieve repression of AHNAK, promoting EMT and invasion
Biological pathway or process:

ceRNA regulation (promotes); invasion (promotes); metastasis (promotes); EMT (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Transwell Assay; CCK8; Western Blot; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

circ_0008194 was corrected with the metastasis of HCC
Description:

circ_0008194 is up-regulated in HCC tumor tissues and promotes invasion/metastasis and EMT in vitro. It functions as a ceRNA by sponging miR-190a, thereby increasing AHNAK expression.
Confidence score:

0.7754
Other information
Title:

CircRNA_0008194 functions as a ceRNA to promote invasion of hepatocellular carcinoma via inhibiting miR-190a/AHNAK signaling pathway.

Journal: Journal of clinical laboratory analysis
Published: 2022
PubMed ID: 35199873
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -