| Expression pattern: |
DN |
| Associated gene: |
p53, p21, CDK4, Cyclin D1, Bcl2 |
| Associated microRNA: |
miR-769-5p |
| Biological function: |
circ-PGAP3 acts as a tumor-inhibiting circRNA that reduces cervical cancer cell proliferation in vitro and retards tumor growth in vivo. |
| Molecular mechanism: |
circ-PGAP3 is transcriptionally elevated by p53 and functions as a cytoplasmic ceRNA sponge for miR-769-5p, relieving miR-769-5p-mediated repression of p53 and activating p53 signaling. |
| Biological pathway or process: |
proliferation (inhibits); ceRNA regulation (promotes); p53 signaling (promotes); cell cycle (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; ChIP / ChIP-seq; Transfection; CCK8; EdU Staining; Colony Formation Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low circ-PGAP3 expression was linked to poor prognosis, larger tumor size, advanced FIGO stage and lymph node metastasis; circ-PGAP3 may be a potential prognostic indicator and therapeutic target for cervical cancer. |
| Description: |
circ-PGAP3 is downregulated in cervical cancer and low expression is associated with poor prognosis and aggressive clinicopathological features. Mechanistically, p53 transcriptionally induces circ-PGAP3, while cytoplasmic circ-PGAP3 sponges miR-769-5p to increase p53 signaling, thereby suppressing cervical cancer cell proliferation and tumor growth. |
| Confidence score: |
0.8632 |