circRNA basic information
circBase ID: -
Name: hsa_circ_CDC25C
Synonym: hsa_circ_005537
Host Gene: CDC25C
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002039
MONDO name: cognitive disorder
Disease details: postoperative cognitive dysfunction
Disease DO ID:
 1561
Disease MeSH ID:
 D019965
Disease NCIt ID:
 C92196
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-5009-5p, hsa-miR-6512-5p, hsa-miR-4753-3p, hsa-miR-6738-3p, hsa-miR-4760-3p
Biological function: unknown
Molecular mechanism: Predicted miRNA sponge interaction based on bioinformatics (circRNA-miRNA prediction).
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; RNase R Treatment; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circRNA_005537 is down-regulated in POCD patient serum and was validated by RT-qPCR consistent with the microarray. The study reports predicted miRNA response elements for this circRNA but does not experimentally establish a specific downstream pathway or function in POCD.
Confidence score:

0.4761
Other information
Title:

Identification of the Potential Key Circular RNAs in Elderly Patients With Postoperative Cognitive Dysfunction.

Journal: Frontiers in aging neuroscience
Published: 2020
PubMed ID: 32655392
Study type:

combined biological and clinical study
Data availability: GSE147277
Code availability: -