| Expression pattern: |
UP |
| Associated gene: |
IFNG, IFNGR2, IL17RA, TNFAIP, ICAM1, FOS, BCL3, BCL2A1, BCL6, SOCS, SGK1 |
| Associated microRNA: |
- |
| Biological function: |
potential biomarker for diagnosing or prognosticating HCC; may regulate functions of peripheral immune cells |
| Molecular mechanism: |
predicted competing endogenous RNA network; miRNA sponge |
| Biological pathway or process: |
ceRNA regulation (other); immune regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Highly expressed circ_0000798 was associated with poor overall survival of HCC patients; circ_0000798 in PBMCs could separate the patients with HCC from the healthy controls (AUC 0.703). |
| Description: |
circ_0000798 (hsa_circ_0000798; host gene BPTF) is up-regulated in PBMCs from HCC patients and is associated with worse overall survival and diagnostic potential (ROC AUC 0.703). Mechanistically, it is predicted to act as a miRNA sponge in a circRNA-miRNA-mRNA network affecting immune-related genes. |
| Confidence score: |
0.6895 |