circRNA basic information
circBase ID: hsa_circ_0001495
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr5:68470703-68471364:+
Genomic location(hg38): chr5:69174876-69175537:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

cervical cancer tissues; paired normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ESRP2, TBL1XR1
Associated microRNA: -
Biological function: Predicted to promote cervical cancer tumorigenesis by regulating epithelial cell proliferation and NOTCH signaling.
Molecular mechanism: Predicted protein interaction with ESRP2 and ceRNA/miRNA sponge mechanism involving TBL1XR1.
Biological pathway or process:

proliferation (promotes); Notch (promotes); ceRNA regulation (promotes)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0001495 was identified as an up-regulated circRNA in cervical cancer. Bioinformatics analyses predicted that it interacts with the RBP ESRP2 and functions as a miRNA sponge competing with TBL1XR1, thereby promoting epithelial cell proliferation and NOTCH signaling in CC tumorigenesis.
Confidence score:

0.1768
Other information
Title:

Identification and characterization of tumorigenic circular RNAs in cervical cancer.

Journal: Cellular signalling
Published: 2020
PubMed ID: 32423867
Study type:

bioinformatics study
Data availability: SRP125806; TCGA cervical cancer cohort; https://doi.org/10.1016/j.cellsig.2020.109669
Code availability: -