| Detected method: |
Q
|
| Detected method confidence |
High
|
| Expression pattern: |
|
| Associated gene: |
TNFSF11 |
| Associated microRNA: |
hsa-miR-149-5p |
| Biological function: |
Circ_CDYL was significantly overexpressed in MN patients and Ang II-induced podocytes compared with control groups. Importantly, loss-of-functional experiments indicated that knockdown of circ_CDYL protected podocytes from Ang II-induced apoptosis. MiR-149-5p was verified as target of circ_CDYL and negatively correlated with circ_CDYL expression in MN patients. |
| Molecular mechanism: |
Knockdown of circ_CDYL-mediated effects on Ang II-induced podocyte cells were abolished by silencing hsa-miR-149-5p. Besides, the upregulation of hsa-miR-149-5p could suppress apoptosis in Ang II-induced podocyte cells by targeting TNFSF11. Under Ang II stimulation, the upregulation of TNFSF11 could increase the expression of TNFSF11 and induce apoptosis in circ_CDYL-silencing podocytes. |
| Survival: |
- |
Supported
No.: |
1 |
| Description: |
circ_CDYL specifically targeted miR-149-5p/TNFSF11 pathway to regulate Ang II-induced apoptosis in podocytes, which might be useful diagnostic biomarkers in MN. |