circRNA basic information
circBase ID: -
Name: hsa_circ_PUM1
Synonym: Circ-Pumilio 1
Host Gene: PUM1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PTC tissues; normal paracancerous samples; tumor tissues
Cell lines:

Nthy-ori 3-1; KTC-1; FTC-133; SW579; TPC-1; 8505C
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: MAPK1
Associated microRNA: miR-21-5p
Biological function: circPUM1 promotes PTC cell growth, metastasis, glycolysis and tumorigenesis; knockdown of circPUM1 suppresses these malignant phenotypes.
Molecular mechanism: circPUM1 acts as a sponge for miR-21-5p, thereby regulating MAPK1 expression through the miR-21-5p/MAPK1 axis.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); glycolysis (promotes); ceRNA regulation (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High circPUM1 expression predicts poor prognosis in PTC patients and may have clinical significance in PTC treatment.
Description:

circPUM1 is up-regulated in papillary thyroid cancer tissues and cell lines, and high expression is associated with poorer overall survival. Functionally, circPUM1 promotes PTC cell growth, migration, invasion, glycolysis and in vivo tumorigenesis. Mechanistically, circPUM1 sponges miR-21-5p to regulate MAPK1, forming a circPUM1/miR-21-5p/MAPK1 axis that supports PTC progression.
Confidence score:

0.7537
Other information
Title:

Knockdown of circPUM1 impedes cell growth, metastasis and glycolysis of papillary thyroid cancer via enhancing MAPK1 expression by serving as the sponge of miR-21-5p.

Journal: Genes & genomics
Published: 2021
PubMed ID: 33481227
Study type:

combined biological and clinical study
Data availability: -
Code availability: -