| Expression pattern: |
UP |
| Associated gene: |
FABP7, MEK/ERK pathway |
| Associated microRNA: |
miR-340-5p |
| Biological function: |
Promotes ccRCC cell DNA synthesis, proliferation, migration, and invasion, and inhibits apoptosis. |
| Molecular mechanism: |
CircPUM1 acts through a ceRNA mechanism by competitively binding miR-340-5p, upregulating FABP7, and activating the MEK/ERK pathway. |
| Biological pathway or process: |
ERK (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Potential circRNA-based therapeutic target for ccRCC. |
| Description: |
CircPUM1 is up-regulated in ccRCC tissues and cell lines. It promotes malignant progression by sponging miR-340-5p, thereby increasing FABP7 expression and activating the MEK/ERK pathway; CircPUM1 knockdown suppresses proliferation, migration and invasion and promotes apoptosis. |
| Confidence score: |
0.73 |